The Resource Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis, (electronic resource)

Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis, (electronic resource)

Label
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report
Title
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS
Title remainder
final report
Statement of responsibility
Robert D. Johnson, Russell J. Lewis
Creator
Contributor
Subject
Language
eng
Summary
Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method
Additional physical form
Also available in print.
Cataloging source
NLM
http://library.link/vocab/creatorName
Johnson, Robert D.
Funding information
Performed by FAA Civil Aerospace Medical Institute under approved task no.
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
QV 132
http://library.link/vocab/relatedWorkOrContributorName
  • Lewis, Russell J
  • United States
  • Civil Aerospace Medical Institute
http://library.link/vocab/subjectName
  • Adrenergic beta blockers
  • Aircraft accidents
  • Hypertension
  • Propanolamines
Label
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis, (electronic resource)
Link
http://purl.access.gpo.gov/GPO/LPS74592
Instantiates
Publication
Note
  • Title from PDF t.p. (viewed May 24, 2006)
  • "May 2005."
  • "DOT/FAA/AM-05/10."
Bibliography note
Includes bibliographical references (p. 6-7)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Dimensions
unknown
Extent
i, 18 p.
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
digital, PDF file.
Specific material designation
remote
System details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/28/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0510.pdf; current access via PURL
Label
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis, (electronic resource)
Link
http://purl.access.gpo.gov/GPO/LPS74592
Publication
Note
  • Title from PDF t.p. (viewed May 24, 2006)
  • "May 2005."
  • "DOT/FAA/AM-05/10."
Bibliography note
Includes bibliographical references (p. 6-7)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Dimensions
unknown
Extent
i, 18 p.
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
digital, PDF file.
Specific material designation
remote
System details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/28/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0510.pdf; current access via PURL

Library Locations

  • AV RepairBorrow it
    100 Larkin Street, San Francisco, CA, 94102, US
  • Anza LibraryBorrow it
    550 37th Avenue, San Francisco, CA, 94121, US
    37.778535 -122.497218
  • Bayview/Linda Brooks-Burton LibraryBorrow it
    5075 3rd Street, San Francisco, CA, 94124, US
    37.732534 -122.391121
  • Bernal Heights LibraryBorrow it
    500 Cortland Avenue, San Francisco, CA, 94110, US
    37.738862 -122.416132
  • Bookmobiles / Mobile OutreachBorrow it
    San Francisco, CA, US
  • Chinatown/Him Mark Lai LibraryBorrow it
    1135 Powell Street, San Francisco, CA, 94108, US
    37.795248 -122.410239
  • Eureka Valley/Harvey Milk Memorial LibraryBorrow it
    1 Jose Sarria Court, San Francisco, CA, 94114, US
    37.764084 -122.431821
  • Excelsior LibraryBorrow it
    4400 Mission Street, San Francisco, CA, 94112, US
    37.727127 -122.433284
  • Glen Park LibraryBorrow it
    2825 Diamond Street, San Francisco, CA, 94131, US
    37.733969 -122.433723
  • Golden Gate Valley LibraryBorrow it
    1801 Green Street, San Francisco, CA, 94123, US
    37.797819 -122.428950
  • Ingleside LibraryBorrow it
    1298 Ocean Ave, San Francisco, CA, 94112, US
    37.724132 -122.456251
  • Main LibraryBorrow it
    100 Larkin Street, San Francisco, CA, 94102, US
    37.779376 -122.415795
  • Marina LibraryBorrow it
    1890 Chestnut Street, San Francisco, CA, 94123, US
    37.801325 -122.434154
  • Merced LibraryBorrow it
    155 Winston Drive, San Francisco, CA, 94132, US
    37.726735 -122.474482
  • Mission Bay LibraryBorrow it
    960 4th Street, San Francisco, CA, 94158, US
    37.775330 -122.393195
  • Mission LibraryBorrow it
    300 Bartlett St, San Francisco, CA, 94110, US
    37.751989 -122.419843
  • Noe Valley/Sally Brunn LibraryBorrow it
    451 Jersey Street, San Francisco, CA, 94114, US
    37.750180 -122.435116
  • North Beach LibraryBorrow it
    850 Columbus Avenue, San Francisco, CA, 94133, US
    37.802585 -122.413280
  • Ocean View LibraryBorrow it
    345 Randolph Street, San Francisco, CA, 94132, US
    37.714138 -122.466002
  • Ortega LibraryBorrow it
    3223 Ortega Street, San Francisco, CA, 94122, US
    37.751163 -122.498094
  • Park LibraryBorrow it
    1833 Page Street, San Francisco, CA, 94117, US
    37.770300 -122.451046
  • Parkside LibraryBorrow it
    1200 Taraval Street, San Francisco, CA, 94116, US
    37.743130 -122.479330
  • Portola LibraryBorrow it
    380 Bacon Street, San Francisco, CA, 94134, US
    37.727098 -122.406361
  • Potrero LibraryBorrow it
    1616 20th Street, San Francisco, CA, 94107, US
    37.760122 -122.397653
  • Presidio LibraryBorrow it
    3150 Sacramento Street, San Francisco, CA, 94115, US
    37.788875 -122.444892
  • Richmond/Senator Milton Marks LibraryBorrow it
    351 9th Ave, San Francisco, CA, 94118, US
    37.781855 -122.468054
  • Sunset LibraryBorrow it
    1305 18th Ave., San Francisco, CA, 94122, US
    37.763354 -122.476307
  • Visitacion Valley LibraryBorrow it
    201 Leland Avenue, San Francisco, CA, 94134, US
    37.712695 -122.407913
  • West Portal LibraryBorrow it
    190 Lenox Way, San Francisco, CA, 94127, US
    37.741341 -122.465883
  • Western AdditionBorrow it
    1550 Scott Street, San Francisco, CA, 94115, US
    37.784121 -122.437503
Processing Feedback ...